Queratitis neurotrófica:Datos preliminares del estudio REPARO presentados en el congreso de la ARVO
– Queratitis neurotrófica:Datos preliminares del estudio REPARO presentados en el
congreso anual de la ARVO [Association for Research in Vision and Ophthalmology]. Este
estudio está diseñado para evaluar la seguridad y posible eficacia de rhNGF en el
tratamiento de esta enfermedad rara e incurable
– El factor de crecimiento nervioso humano recombinante (rhNGF), una
molécula de uso oftalmológico desarrollada por Dompé, es el primer tratamiento
potencial para la queratitis neurotrófica, una enfermedad para la que no existe un
tratamiento efectivo y afecta a menos de una de cada 5.000[1] personas.
– El rhNGF es la primera aplicación clínica de la investigación desarrollada
por Rita Levi Montalcini (ganadora del Premio Nobel de Medicina en 1986) sobre el
factor del crecimiento nervioso.
– Los resultados preliminares del estudio de fase I confirman la tolerabilidad
de rhNGF y muestran un alto porcentaje de pacientes que lograron una completa
curación de las lesiones de la córnea.
– El rhNGF está ahora en desarrollo de fase II y la reclutación de pacientes
está en marcha. El estudio se está llevando a cabo en 39 centros de 9 países
europeos.
Dompé, una compañía farmacéutica italiana, está creando nuevos prospectos para el
tratamiento de las úlceras de la córnea en pacientes afectados por la queratitis
neurotrófica, una condición ocular poco frecuente no curable que afecta a menos de una
de cada 5.000 personas en todo el mundo[1].
El rhNGF (el factor de crecimiento nervioso humano recombinante) está en desarrollo
clínico en el estudio REPARO, que se está realizando en 39 centros en 9 países
europeos. Los datos preliminares de la fase I del estudio, que implican a pacientes
afectados por la queratitis neurotrófica entre moderada y grave, se presentaron en el
congreso anual de ARVO (Orlando, EE. UU., 4-8 de mayo de 2014) y demostraron que el rhNGF
es bien tolerado.
El estudio examinó a 18 pacientes (7 hombres y 11 mujeres) que sufrieron queratitis
neurotrófica entre moderada o grave, resultado de la diabetes, infecciones oculares
causadas por el virus del herpes, intervenciones neuroquirúrgicas y otras enfermedades
relacionadas. Los pacientes reclutados en el estudio, que no respondieron a los
tratamientos médicos disponibles, se dividieron en cuatro grupos. En el primer grupo, los
pacientes recibieron una solución de gotas para el ojo de uso tópico a una dosis de 10
microg/ml. En el segundo grupo, se administró un vehículo simple. En el tercer grupo, se
administró una dosis de 20 microg/ml y, en el cuarto grupo, se administró placebo. Al
final del tratamiento, 11 pacientes tuvieron una mejora notable en las condiciones de la
córnea. Aunque los datos aún están «enmascarados» y, por tanto, aún no se sabe qué
pacientes recibieron rhNGF y cuáles recibieron el placebo, la resolución completa de las
lesiones corneales se registró en la mayoría de los pacientes, con porcentajes similares
en los dos grupos tratados con rhNGF a diferentes dosis, así como un aumento en la
sensibilidad de la córnea en aproximadamente uno de cada tres pacientes.
1. Sacchetti M., Lambiase A., Diagnosis and management of neurotrophic keratitis.
Clinical Ophthalmology 2014; 8: 571-579.
«Estos resultados son de gran importancia en el curso del desarrollo clínico de
rhNGF, un fármaco candidato que se origina desde la investigación desarrollada por la
ganadora del Premio Nobel, Rita Levi Montalcini,» explicó Eugenio Aringhieri, consejero
delegado del grupo Dompé. «Nuestros investigadores fueron los primeros en identificar una
molécula biotecnológica de NGF para uso oftalmológico. Los resultados de este estudio
destacan el potencial de NGF en el campo de la oftalmología. Dompé continuará siguiendo
su fuerte compromiso con los pacientes, centrando su I+D en áreas caracterizadas por
altas necesidades médicas no cubiertas, como la queratitis neurotrófica.»
«La queratitis neurotrófica se caracteriza por su gravedad y curso degenerativo,
resultante de la innervación reducida de la cornea como resultados de varios estados de
enfermedad (por ejemplo, diabetes, herpes, intervenciones quirúrgicas) que pueden incluso
conducir a consecuencias discapacitadoras, como la ulceración y perforación de la
córnea, que resulta en la pérdida de las funciones visuales», explicóel profesor
Stefano Bonini, jefe del Departamento de Oftalmología en el BioMedico Campus de Roma e
investigador jefe del estudio REPARO. «Hoy, tras años de estudio, estamos orgullosos de
poder argumentar nuestra investigación, que está también confirmada por los
prometedores resultados del estudio REPARO. Un resultado alentador que también ha venido
del sector industrial, mediante experiencia y visión, ha hecho posible producir un
fármaco bajo la evaluación clínica en un corto periodo de tiempo.»
La molécula está también en experimentación para el tratamiento del síndrome del
ojo seco y la retinitis pigmentosa.
Acerca de Dompé
http://www.dompe.com
Declaraciones prospectivas
Este comunicado podría contener declaraciones de futuro. Dompé cree de forma firme
que las expectativas reflejadas en las declaraciones de futuro son razonables y están
construidas sobre presunciones destacadas. A pesar de ello, debido a su naturaleza
importante, las declaraciones de futuro están sujetas a incertidumbres, incluyendo las
inherentes en el contexto de I+D y las asociadas a las decisiones realizadas por las
autoridades normativas. Así, Dompé no garantiza cumplimiento con los resultados
esperados respecto a lo mencionado anteriormente.
Dompe
CONTACT: CONTACTO Alessandro Aquilio Responsable de Asuntos Públicos y Comunicaciones Corporativas E-mail: alessandro.aquilio@dompe.it +39-02-58383-556 | +39-334-6550628
——-
Perfil: profile
# Harvard University: A Legacy of Excellence and Innovation
## A Brief History of Harvard University
Founded in 1636, **Harvard University** is the oldest and one of the most
prestigious higher education institutions in the United States.
Located in Cambridge, Massachusetts, Harvard has built a
global reputation for academic excellence, groundbreaking research, and influential alumni.
From its humble beginnings as a small college established to educate clergy, it has evolved into a world-leading university that shapes the future across various disciplines.
## Harvard’s Impact on Education and Research
Harvard is synonymous with **innovation and intellectual leadership**.
The university boasts:
– **12 degree-granting schools**, including the renowned
**Harvard Business School**, **Harvard Law School**, and **Harvard Medical School**.
– **A faculty of world-class scholars**, many of whom are Nobel laureates, Pulitzer Prize winners,
and pioneers in their fields.
– **Cutting-edge research**, with Harvard leading initiatives in artificial intelligence, public health, climate change, and more.
Harvard’s contribution to research is immense, with billions of dollars allocated to scientific discoveries
and technological advancements each year.
## Notable Alumni: The Leaders of Today and Tomorrow
Harvard has produced some of the **most influential
figures** in history, spanning politics, business,
entertainment, and science. Among them are:
– **Barack Obama & John F. Kennedy** – Former U.S.
Presidents
– **Mark Zuckerberg & Bill Gates** – Tech visionaries (though Gates
did not graduate)
– **Natalie Portman & Matt Damon** – Hollywood icons
– **Malala Yousafzai** – Nobel Prize-winning activist
The university continues to cultivate future leaders who shape industries and drive
global progress.
## Harvard’s Stunning Campus and Iconic Library
Harvard’s campus is a blend of **historical charm
and modern innovation**. With over **200 buildings**,
it features:
– The **Harvard Yard**, home to the iconic
**John Harvard Statue** (and the famous “three lies” legend).
– The **Widener Library**, one of the largest university libraries in the world, housing
**over 20 million volumes**.
– State-of-the-art research centers, museums, and performing arts venues.
## Harvard Traditions and Student Life
Harvard offers a **rich student experience**, blending academics with vibrant traditions,
including:
– **Housing system:** Students live in one of 12 residential houses,
fostering a strong sense of community.
– **Annual Primal Scream:** A unique tradition where students de-stress
by running through Harvard Yard before finals!
– **The Harvard-Yale Game:** A historic football rivalry that unites alumni
and students.
With over **450 student organizations**, Harvard students engage
in a diverse range of extracurricular activities, from entrepreneurship to performing arts.
## Harvard’s Global Influence
Beyond academics, Harvard drives change in **global policy,
economics, and technology**. The university’s
research impacts healthcare, sustainability, and artificial intelligence, with partnerships
across industries worldwide. **Harvard’s endowment**, the largest of any university, allows it to fund scholarships, research,
and public initiatives, ensuring a legacy of impact for generations.
## Conclusion
Harvard University is more than just a school—it’s a **symbol of excellence, innovation, and leadership**.
Its **centuries-old traditions, groundbreaking discoveries, and transformative education** make
it one of the most influential institutions in the world.
Whether through its distinguished alumni, pioneering research, or vibrant student
life, Harvard continues to shape the future in profound ways.
Would you like to join the ranks of Harvard’s legendary scholars?
The journey starts with a dream—and an application!
https://www.harvard.edu/
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Balanset-1A: Innovative Portable Balancer & Vibration Analyzer
Industrial-grade Dynamic Balancing Solution
Balanset-1A represents an advanced solution for vibration correction of rotors in their own bearings, manufactured by Estonian company Vibromera OU. The device provides professional equipment balancing at €1,751, which is significantly cheaper than traditional vibration analyzers while maintaining superior measurement accuracy. The system allows in-place balancing directly at the equipment’s operational location without necessitating disassembly, which is vital for reducing production downtime.
About the Manufacturer
Vibromera OU is an Estonian company concentrating in the development and manufacturing of equipment for technical diagnostics of industrial equipment. The company is registered in Estonia (registration number 14317077) and has offices in Portugal.
Contact Information:
Official website: https://vibromera.eu/shop/2/
Technical Specifications
Detection Parameters
Balanset-1A delivers accurate measurements using a dual-channel vibration analysis system. The device measures RMS vibration velocity in the range of 0-80 mm/s with an accuracy of ±(0.1 + 0.1?Vi) mm/s. The working frequency range is 5-550 Hz with optional extension to 1000 Hz. The system supports rotation frequency measurement from 250 to 90,000 RPM with phase angle determination accuracy of ±1 degree.
Working Principle
The device utilizes phase-sensitive vibration measurement technology with MEMS accelerometers ADXL335 and laser tachometry. Two mono-directional accelerometers measure mechanical oscillations proportional to acceleration, while a laser tachometer generates impulse signals for determining rotation frequency and phase angle. Digital signal processing includes FFT analysis for frequency analysis and proprietary algorithms for automatic calculation of balancing masses.
Full Kit Package
The standard Balanset-1A delivery includes:
Measurement unit with USB interface – main module with embedded preamplifiers, integrators, and ADC
2 vibration sensors (accelerometers) with 4m cables (optionally 10m)
Optical sensor (laser tachometer) with 50-500mm measuring distance
Magnetic stand for sensor mounting
Electronic scales for exact measurement of corrective masses
Software for Windows 7-11 (32/64-bit)
Plastic transport case
Complete set of cables and documentation
Performance Capabilities
Vibrometer Mode
Balanset-1A works as a complete vibration analyzer with features for measuring overall vibration level, FFT spectrum analysis up to 1000 Hz, calculating amplitude and phase of the fundamental frequency (1x), and continuous data recording. The system delivers visualization of time signals and spectral analysis for equipment condition diagnostics.
Balancing Mode
The device supports one-plane (static) and two-plane (dynamic) balancing with automatic calculation of corrective masses and their installation angles. The unique influence coefficient saving function enables considerable acceleration of subsequent balancing of identical equipment. A dedicated grinding wheel balancing mode uses the three-correction-weight method.
Software
The user-friendly program interface offers step-by-step guidance through the balancing process, making the device available to personnel without specialized training. Key functions include:
Automatic tolerance calculation per ISO 1940
Polar diagrams for imbalance visualization
Result archiving with report generation capability
Metric and imperial system support
Multilingual interface (English, German, French, Polish, Russian)
Usage Domains and Equipment Types
Industrial Equipment
Balanset-1A is successfully employed for balancing fans (centrifugal, axial), pumps (hydraulic, centrifugal), turbines (steam, gas), centrifuges, compressors, and electric motors. In production facilities, the device is used for balancing grinding wheels, machine spindles, and drive shafts.
Agricultural Machinery
The device provides special value for agriculture, where uninterrupted operation during season is vital. Balanset-1A is used for balancing combine threshing drums, shredders, mulchers, mowers, and augers. The ability to balance on-site without equipment disassembly permits preventing costly downtime during busy harvest periods.
Specialized Equipment
The device is effectively used for balancing crushers of various types, turbochargers, drone propellers, and other high-speed equipment. The RPM frequency range from 250 to 90,000 RPM covers essentially all types of industrial equipment.
Superiority Over Alternatives
Economic Efficiency
At a price of €1,751, Balanset-1A offers the functionality of devices costing €10,000-25,000. The investment breaks even after preventing just 2-3 bearing failures. Cost reduction on external balancing specialist services totals thousands of euros annually.
Ease of Use
Unlike complicated vibration analyzers requiring months of training, mastering Balanset-1A takes 3-4 hours. The step-by-step guide in the software enables professional balancing by personnel without specific vibration diagnostics training.
Portability and Autonomy
The complete kit weighs only 4 kg, with power supplied through the laptop’s USB port. This allows balancing in outdoor conditions, at distant sites, and in difficult-access locations without external power supply.
Universal Application
One device is adequate for balancing the most extensive spectrum of equipment – from small electric motors to large industrial fans and turbines. Support for single and dual-plane balancing covers all standard tasks.
Real Application Results
Drone Propeller Balancing
A user achieved vibration reduction from 0.74 mm/s to 0.014 mm/s – a 50-fold improvement. This demonstrates the remarkable accuracy of the device even on small rotors.
Shopping Center Ventilation Systems
Engineers effectively balanced radial fans, achieving decreased energy consumption, removed excessive noise, and extended equipment lifespan. Energy savings recovered the device cost within several months.
Agricultural Equipment
Farmers note that Balanset-1A has become an essential tool preventing costly breakdowns during peak season. Decreased vibration of threshing drums led to lower fuel consumption and bearing wear.
Pricing and Delivery Terms
Current Prices
Complete Balanset-1A Kit: €1,751
OEM Kit (without case, stand, and scales): €1,561
Special Offer: €50 discount for newsletter subscribers
Bulk Discounts: up to 15% for orders of 4+ units
Ordering Options
Official Website: vibromera.eu (recommended)
eBay: verified sellers with 100% rating
Industrial Distributors: through B2B channels
Payment and Shipping Terms
Payment Methods: PayPal, credit cards, bank transfer
Shipping: 10-20 business days by international mail
Shipping Cost: from $10 (economy) to $95 (express)
Warranty: factory warranty
Technical Support: included in price
Conclusion
Balanset-1A stands as an perfect solution for organizations seeking to deploy an efficient equipment balancing system without major capital expenditure. The device opens up access to professional balancing, enabling small companies and service centers to deliver services at the level of large industrial companies.
The mix of accessible price, ease of use, and professional functionality makes Balanset-1A an essential tool for modern technical maintenance. Investment in this device is an investment in equipment stability, lower operating costs, and increased competitiveness of your enterprise.
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